药学英语之减肥药原理讲解.ppt

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1、Generic Name:Sibutramine hydrochlorideProduct Name:Reductil/Ectiva,Product name:Qu MeiGeneric Name:Sibutramine hydrochloride,SibutramineFormula:C17H26Cl N,molecule,Chemical structure,Indications:obesity(肥胖症，多脂)！,pharmacology,Sibutramine is a neurotransmitter(神经递质)reuptake（重吸收）inhibitor that reduces

2、the reuptake of serotonin（血清素),norepinephrine（去甲肾上腺素）,and dopamine,thereby increasing the levels of these substances in synaptic clefts（突触间隙）and helping enhance satiety（饱满感）;the serotonergic（5-羟色胺能）action,in particular,is thought to influence appetite.,contraindications,Sibutramine is contraindicate

3、d in:1 Psychiatric(精神病学的)conditions as bulimia nervosa（神经性贪食症）,anorexia（厌食症）,serious depression or preexisting mania（狂躁症）2 Patients below 18 years of age 3 Concomitant（伴行的，并发的）treatment with a MAO inhibitor（单胺氧化酶抑制剂）,antidepressant or other centrally active drugs,particularly other anoretics（消瘦剂，减食欲

4、剂）4 Hypertension that is not sufficiently controlled(caution in controlled hypertension)5 Existing pulmonary hypertension（肺动脉高血压）6 Pregnant and lactating（泌乳）women,side effects!,Frequently encountered side effects are:dry mouth,paradoxically increased appetite,nausea(恶心),strange taste in the mouth,up

5、set stomach,constipation（便秘）,trouble sleeping,dizziness,drowsiness（困倦）,menstrual cramps/pain,headache,flushing（面红）,or joint/muscle pain.,The following side effects are infrequent but serious and require immediate medical attention:cardiac arrhythmias（心律不齐）,paresthesia（感觉异常）,mental/mood changes(e.g.,

6、excitement,restlessness,confusion,depression,rare thoughts of suicide).,Symptoms that require urgent medical attention are seizures（癫痫发作）,problems urinating（排尿）,abnormal bruising（碰伤）or bleeding,hematemesis（呕血）,fever and rigors（僵直）,chest pain,hemiplegia,（半身不遂）abnormal vision,dyspnea（呼吸困难）and edema.（水肿）,Suggestion!Dont take QU Mei or any kind of medicine whose main ingredient is Sibutramine.More exercise and less food is the golden key for losing weight.If some medicine must be taken for helping losing weight,I recommend Wei Ting.,