癫痫脑病qinjiong ppt课件.ppt
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1、癫痫性脑病,癫痫性脑病,IntroductionDefinitionExplanationExamplesConcluding Remarks,癫痫性脑病 Epileptic Encephalopathy,脑病:Encephalo-pathy癫痫性脑病:癫痫 Epileptic+脑病癫痫所致(相关)的脑病X脑病所致(相关)的癫痫,ILAE 2001,ILAE 2001,Epileptic Encephalopathy,A condition in which the epileptiform abnormalities themselves are believed to contribute
2、 to the progressive disturbance in cerebral function.脑功能障碍,进展性癫痫性异常(放电本身)所致,ILAE 2001,Summary of key recommendations from the Commission on Classification and Terminology For Discussion at the ICE in Budapest,ILAE 2009,Embodies the notion that epileptic activity lead to severe cognitive and behavior
3、al impairment above and beyond what from the underlying pathology(e.g.cortical malformation)alone(癫痫样活动本身的意义,而不是基础病因)seizures themselves contribute to the cognitive impairments(发作本身的意义)Although may occur at any age,most common and severe in the developing brain(发育期),Epileptic Encephalopathy,Inherent
4、 in this concept is the idea thatby suppressing or preventing the epileptic activity,one may improve the cognitive and behavioral outlook of the disorder.(干预的意义)In the developing brain,rapid effective intervention should and can be used before the abnormal epileptic activity interferes irrevocably w
5、ith normal processes of brain development.(快速有效的干预)The best known and most common of these are West,LGS,Dravet,LKS-CSWS,and Doose syndromes.(包括多个综合征-有待更多研究),Epileptic Encephalopathy,癫痫性脑病,Definition Explanation癫痫性脑病具有相对独特而复杂的临床脑电特征精神行为认知损伤癫痫样活动本身所致独立于基础脑疾病包括一组预后不良的综合征West,LGS,Dravet,LKS-CSWS,and Doo
6、se,etc.及时干预可能改善认知的转归多见于发育时期,癫痫性脑病,Introduction to Epileptic EncephalopathyExamples:Epileptic EncephalopathiesOhtahara SyndromeEarly myoclonic encephalopathy(EME)Dravet SyndromeLennox-Gastaut SyndromeConcluding Remarks,癫痫和癫痫综合征分类(简化,ILAE 2001),将各种癫痫综合征分成8组婴儿和儿童特发性局灶性癫痫(4)家族性(常染色体显性遗传)局灶性癫痫(5)症状性(或可能为



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