《儿童胃炎英》PPT课件.ppt

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1、GASTRITIS IN CHILDREN,Chongqing Childrens HospitalDivision of Infectious Disease and Gastroenterology,2,Gastritis Acute Gastritis Chronic Gastritis,3,Acute Gastritis,4,Diffination Etiology&Pathogenesis Pathology,Acute gastritis,5,Food and Drugs:Severe stress state:Acute infection:Corrosive substance

2、s:,Vagal stimulationAcid secretionRelease of vasoactive amine and cytokinesMicrocirculation disdurbanceGastric mucosal ischemiaImpairment of mucosal and mucous barriersBack-diffusion of hydrogen ions,Shock,hydrocephalus,sudden trauma,serious infection,major operation,etc,Acute gastritis,Etiology&Pat

3、hogenesis,6,ManifestationsA sudden onsetTypical manifestations:epigastric pain,nausea,vomiting,watery diarrheaFever:caused by bacterial infection or its toxinsComplications:dehydration,electrolyte disturbances,acid-base imbalance,UGI bleeding,Acute gastritis,Manifestations,7,Diagnosis,Acute simple g

4、astritis Historysymptoms and signsGI endoscopy&Biopsy(if necessary),Diffusive hyperemia and edema of the gastric mucosa Acute inflammation:neutrophilic infiltration in the lamina propriaMay accompanied with punctate hemorrhage and mild corrupt lesion,8,A.Remove of offending agents Quit all irritants

5、 or stimulus:drugs,alcohol Management of the original diseasesB.Symptomatic treatment 1)Replacement of fluid and electrolyte loss 2)Spasmolysant:Atropine,Belladonna 4)Antiemetic drugs:Domperidone 3)Special management for upper GI bleedingC.Protection of gastric mucosa and inhibition of gastric acid

6、Mucosal protector Antacids:H2-RA,PPI,Treatment,9,Chronic gastritis,10,The top two reasons for recurrent abdominal pain in children are chronic gastritis&PUD,An estimated 10%school age children is affected by recurrent abdominal pain.,11,By definition,is a histopathological entity characterized by ch

7、ronic inflammation of the stomach mucosa.It may present with an array of symptoms,the most common being nonspecific recurrent abdominal pain in children.High frequency in children,12,Classification,Update Sydney System in 1996 Superficial Chronic Gastritis Atrophic Specific types,13,Etiology,Helicob

8、acter pylori(HP)Bile reflux Dietary Habit Sequela of acute gastritis Drugs Psychological and genetic factors:Emotional stressChronic DiseaseOther factors,14,Helicobacter plori,15,H Pylori is considered to infect virtually all patients with chronic active gastritis and thought to be spread from perso

9、n to person via oral-oral and/or fecal-oral routes.,16,Clinical manifestation,Recurrent abdominal pain Dyspeptic symptoms Excessive belching,acid regurgitation,hiccups,nausea,vomiting,diarrhea Growth retardation Upper GI bleeding,17,Clinical manifestation,A relatively minor manifestation of diseases

10、 The smaller the children the more atypical manifestation,18,Auxiliary examinations,Gastroscopic examination is the most reliable method for diagnosis of gastritisBiopsyX-ray:Barium meal examinationHP detection,19,Diagnostic methods of HP infectionRapid urease test Urea breath test(C13)Histology Ser

11、um Antibodies to HPBacterial Culture Testing for HP stool antigenPolymerase chain reaction,20,Diagnosis,Recurrent abdominal pain and/or dyspeptic symptom in children,Gastroendoscopic examination,History:Inappropriate dietary habits,family history,medication taking,psychological stress,21,Differentia

12、l Diagnosis,EnterositeEnterospasmAbdominal epilepsy,22,Treatment,Etiologic treatment:Dietary adjustment,quit irritant drugs or other stimulus,HP eradication,try to control the bile reflux,etcSymptomatic treatmentProtection of gastric mucosaInhibition of gastric acid,23,HP eradication,Triple regimens

13、,24,Prevention of duodenogastric Reflux.Doperidome Cisapride Reducing gastric acid secretion.H2RT(for 4 weeks):Ranitiding Cimetidine PPI(for 2 weeks)Omeprazole Lansoprazole,25,Enhancing mucosal defense Bismuth compounds Sucrafate Symptomatic treatment Atropine Belladonna,26,Normal Gastric Mucosa,NGM

14、,27,gastric mucosal edema,NGM,28,Hemorrhagic gastritis,Hemorrhagic gastritis with multiple intramural bleeding spots,NGM,29,Gastric Lymphoid Hyperplasia,Normally there is no organized lymphoid tissue in the stomach.,Multiple papules in the antrum corresponding to lymphoid hyperplasia induced by Heli

15、cobacter pylori infection.,NGM,30,Alkaline Reflux Gastritis,Normal gastric mucosa,Stomach mucosa diffusely covered with bile-stained mucus.,NGM,31,Gastric Candidiasis,Normal gastric mucosa,Gastric candidiasis with extensive green-white exudates covering the antrum.,32,Chronic Antral Gastritis,Increased visibility of the antral vascular pattern with findings compatible with chronic athrophic gastritis associated with H.pylori infection.,The rugal folds of the body running longitudinally towards the antrum.,33,Thank you.,