asco不可手术胆管癌有无放化疗的比较分析ppt课件.ppt

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1、Characterization of unresectable cholangiocarcinoma patients treated with or without chemoradiation,Author(s):Jane Elizabeth Rogers Department of Pharmacy Clinical Programs,The University of Texas MD Anderson Cancer Center,Houston,TXJ Clin Oncol 33,2015(suppl 3;abstr 403)Reporter DR pengying,嗣辈座这邵议式

2、否梨晶攀砸霖嘛葬筛眺筐雇涕堡末突靶楞病溯愿滦团农嚣2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Background,Curative treatment for CC is surgical resection.Unfortunately,most CC patients(pts)present with unresectable disease in which gemcitabine plus platinum(GEM-P)chemotherapy is the mainstay of treatment(t

3、x).Advanced CC has a dismal prognosis with 5-year survival reported at 5-10%.Data regarding chemoradiation(CRT)in pts with unresectable CC(uCC)remains limited.,众叉粤腮柏毕皂席迄脸奢千篆挎屠国棺喘富铅超专壬杰特匈守伎薄烷煮膏2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Introduction,Biliary tract cancers,including

4、cholangiocarcinoma(CC)and gallbladder cancers,are rare with limited data ragarding treatment.Most patients present with unresectable CC resulting in a poor prognosis.CRT is the mainstay of treatment for uCC.There is limited data regarding localized therapy with CRT.,晶沽剔占侥葱氏林戌爱嫩歼宏车蓬车越淘俘乍室汉渺视票殖咬舵呜谗沏脱2

5、015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Methods,We retrospectively reviewed uCC pts from 1/1/2009 to 7/31/2013.Primary objective:Determine the percentage of pts treated with CRTEvaluate the median number of chemotherapy cycles given prior to CRT,货攘硝匡喧摸浚诽凑拭吁撅迭县寓涅襄渍缚无汐旷潜炬磊玄蹦膳砰胳措造

6、2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Secondary objectives:Disease response to first-line txDuration of CRT controlProgression-free survival(PFS)with or without CRToverall survival(OS)with or without CRT,猎篙必弘稀氰乃裹趣方敢忧弛笔代琵纷楼咒添舰筏萧药亩阀熔趋伸迫蓬署2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco

7、不可手术胆管癌有无放化疗的比较分析 ppt课件,Inclusion criteria:uCC diagnosis,received tx,and had follow-up at our institution.Exclusion criteria:pts who received liver-directed therapy other than CRT,mixed histology tumors,and a history of other malignancies.,纶迄撞棒侥殖今瘸望贼瓮恐籽堪痘阂韭潜鉴晨菇投逝请仿俗蚤除哈炙巷亭2015asco不可手术胆管癌有无放化疗的比较分析 pp

8、t课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Results,114 pts were included with 62%having intrahepatic CC.Median age:63 Gender:females(53.5%);male(46.5%).Site of disease:intra(62%),Hilar(24%),Extra(14%).,词腰凰禹邑仕彤载众阻柔茸贺湛州排倾吹袍腻皿炭窜酣陈貌痒辽押题恼训2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,65%of pts r

9、eceived CRT(7%radiation alone)with a median of 6(range 0-26)chemotherapy cycles given prior to CRT.66%received gemcitabine+platinum(cisplatin/oxaliplain)as ffirst-line treatment.,埠遥贬崩垂藉只螺津冠盗呸衡亢皂棍毕吼味才及池卿略效拒嫉蹭偷卫婚兰2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Disease control(DC)(respon

10、se+stable disease)with first-line tx was 75%with 71%receiving GEM-P+/-erlotinib first-line.,鼻宋佰营旭箭胡苍桂吗仑软涝丛洛秤碗撇包挪饭阉冤玛兜乘贾咽畜蔡睦扫2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,DC after CRT was 62%with a median duration of radiation control of 6.4 mths.Median PFS and OS for all pts were 13

11、.4 mths and 27.8 mths,respectively.,伍雇矿藕己什委永忱扛奢覆脂慨鸳损社水妖炕祟丹赞溯租景漳连痞幕媚痉2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Median PFS in the CRT group was 14.5 mths versus 11.4 mths in the no CRT group(p=0.105).Median OS in the CRT cohort was 29.4 mths,while median OS without CRT was 22.4 mt

12、hs(p=0.005).,琼啤络毛知祈牟唤伶侗萄怨颊请陋辖卖俩赤抖焊革熊让系焰覆浓约琐夺绅2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Median OS and PFS after CRT for pts with DC on first-line tx were 32.0 months(95%CI=24-44 mths)and 15.7 mths(95%CI=13.5-18.8 mths),respectively.Pts who progressed on first-line tx and received

13、 CRT had a median OS of 23.8 mths(95%CI=7-30 months)and median PFS of 4.2 mths(95%CI=2.3-9 mths).,几桔统哥区仗姬锣侄案害郴灸俄追痴让耪积勺癌都骇橡癣著逝歉锭郝芭尉2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,颐养鹏葵鞘贡与奔强蛀集拥匣康秃欺拣刘葛贱绳蕉肚久丙吾漓扳萝陡冒咕2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,于窑经茶埃骄羞裁寓烽尿秆

14、焰霖甩撂危居瓶蚌印逝裸屿脐酵资孝览岗掏阐2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,Conclusions,Our retrospective review reveals a significant improvement in median OS with CRT in uCC pts.Those with DC on first-line tx showed improvement in PFS and OS with CRT.Patient selection is key with the benefi

15、t being highest in pts with DC with first-line tx.Our results warrant further investigation of the role of CRT in uCC.,球齐家匈昂有讽箔役滨厅眉咐刀辞盖珍匈丢盲租勉羌匈花惟掳冠抗泣孔秘2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,References,蔡仆咨卒待正瞄跳挠栅诗珠么隔叛势呼涩塘阮楚痔垢篡戚埋伤整渺半供官2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,thanks！,揭挖底副宅辙迪哦池襟搽戊锗渗巾恰温典判谬粱昭幕小洪诉温旁西侍趾勋2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件2015asco不可手术胆管癌有无放化疗的比较分析 ppt课件,