诊断学呕血与便血 英文版课件.ppt

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1、Diagnosis ofGastrointestinal Bleeding,Hematemesis and Hematochezia 呕血与便血,The approach to gastro-intestinal(GI)bleeding is tailored to the manner of appearance.,Is bleeding acute or chronic?,Intensive care,Where is the source of bleeding?,Empiric therapy,Diagnosis,Treatment,(经验治疗),What is the causes

2、of bleeding?,Recognition of hemorrhage,Intensive care,Where is the source of bleeding?,Empiric therapy,Diagnosis,Treatment,(经验治疗),What is the causes of bleeding?,Is bleeding acute or chronic?,Recognition of hemorrhage,Clinical Manifestations,1 Manner of bleeding presentation2 Hypovolemia(低血容量)or sho

3、ck3 Anemia(贫血),Recognition of hemorrhage,Patients manifest blood loss,1)Hematemesis 呕 血 Bloody vomitus,either fresh and bright red or older and“coffee-ground”(hematin 酸化正铁血红素)in character Hemoptysis?Nosebleeding?,Manner of bleeding presentation,from the GI tract in five ways:,2)Melena 黑 便 Shiny,blac

4、k,sticky,foul-smelling stool degradation of blood exogenous stool darkeners iron bismuth(铋剂),Manner of bleeding presentation,Manner of bleeding presentation,3)Hematochezia 便 血 bright red or maroon blood from the rectum pure blood blood intermixed with formed stool bloody diarrhea,Manner of bleeding

5、presentation,4)Occult 隐 血 detected only by testing the stool with a monoclonal antibody for human hemoglobin,Estimate amount of bleeding from upper GI tract,510 ml/d OB+5070 ml/d Melena 250300 ml in short time Hematemesis,Manner of bleeding presentation,without any objective sign of bleeding with sy

6、mptoms of blood loss dizziness,dyspnea,angina cordis(心绞痛),or even shock digital examination(指检)of the rectum,Hypovolemia or shock,Speed and volume of blood lossWeakness,giddiness(眩晕),oliguria,(少尿)cold extremity,sweatingVital signs:tachycardia,(心动过速)hypotention(低血压),Anemia,paledizzinesspalpitation,ea

7、sy fatigabilitydyspnea angina cordis,Is bleeding acute or chronic?,1)Bleeding speed Hematemesis of fresh blood generally indicates a more severe bleeding episode than melena,which occurs when bleeding is slow enough to allow time for degradation of blood,Is bleeding acute or chronic?,2)Hematocrit bl

8、eeding slowly hypochromic(血红蛋白过少)microcytic(小细胞)red blood cells mean corpuscular volume(MCV，平均血球压积)of the cells may be low,Is bleeding acute or chronic?,If blood loss is acute,the hematocrit dose not change during the first few hours after hemorrhage About 24 to 72 hours later,plasma volume is large

9、r than normal and the hematocrit is at its lowest point,Is bleeding acute or chronic?,Hematocrit changesA Before bleeding B Immediately after bleeding C 2472 hours after bleeding,Is bleeding acute or chronic?,3)Blood pressure and heart ratedepend on amount of blood loss suddenness of blood loss exte

10、nt of cardiac and vascular compensation,postural hypotension-early physical findingtachycardia-greater loss,compensate recumbent(卧位)hypotension-final results,Is bleeding acute or chronic?,Is bleeding acute or chronic?,Postural hypotension A postural drop in blood pressure of 10 to 15 mm Hg,Is bleedi

11、ng acute or chronic?,4)Bowel sound Active bowel sound usually be presented in acute bleeding from GI tract,Emergent and intensive care,Initially vital signs supine and upright blood pressure pulse,If blood loss is significant,intravenous fluids must be started,Saline or other balanced electrolyte so

12、lutions are most rapidly available,Blood is sent to the plete blood count clotting studies routine chemistry studies.Blood for typing and cross-matching is sent to the blood bank.,Where is the source of bleeding?Localization,Upper GI bleeding:bleeding from a source proximal to the ligament of Treitz

13、.Lower GI bleeding:bleeding from a site distal to the ligament of Treitz.,Localization,Treitz:The ligament of Treitz is an anatomic landmark for the duodenal-jejunal junction.,Localization,Differentiating features of upper GI and lower GI bleedingUpper GILower GIManifestationHematemesisHematocheziam

14、elenaNasogastric aspirateBloodyClearBUNElevatedNormalBowel soundHyperactiveNormal,Upper GI tract bleeding?,Clinical manifestationBowel soundNasogastric tube,Hematemesis,Melena,Hematochezia,More proximal lesions producehematemesis or melena,whereas more distal lesions are more likely to produce hemat

15、ochezia.,If hematochezia is from an upper GI source,it usually reflects a massive bleed(i.e.,greater than 1000 ml).,What is the causes of bleeding?,90%upper GI bleeding is due to four lesions:1)peptic ulcer(消化性溃疡)2)hemorrhagic gastritis(胃炎)3)esophageal or gastric varices(静脉曲张)4)gastric cancer,peptic

16、 ulcer,hemorrhagic gastritis,esophageal varices,gastric cancer,Causes of gastrointestinal bleeding,Mallory-Weiss tear 食道-贲门撕裂伤,Causes of gastrointestinal bleeding,Portal-hypertensive gastropathy 门脉高压胃病Ancylostomiasis 钩虫病Post-sphincterotomy 括约肌切开术后,Causes of gastrointestinal bleeding,Colorectal cance

17、r Colitis Large hemorrhoid大痔 Rectum tear肛裂 Vascular anomalies Hematologic diseases,Diagnostic approach to gastrointestinal bleeding,1 History and physical examination2 Endoscopy 3 Barium radiography4 Angiography5 Nuclear scintigraphy,History and physical examination,A history of previously docu-ment

18、ed GI tract disease determined by radiography,endoscopy,or surgical procedures is very useful.,Diagnostic approach to GI bleeding,Diagnostic approach to GI bleeding,Patients with hepatitis B or chronic active liver disease may present with painless hematemesis from esophageal varices.,Diagnostic app

19、roach to GI bleeding,Patients with forceful,retching(干呕)or multiple episodes of vomiting of food prior to the onset of hematemesismay be bleeding from MalloryWeisstears of the gastroesophageal junction.,Diagnostic approach to GI bleeding,A history of epigastric(上腹部)burning pain promptly relieved by

20、foodor antacids(抗酸剂)or nocturnal(夜间)pain suggests peptic ulcer disease,particularly duodenal(十二指肠)ulcer.,Diagnostic approach to GI bleeding,Colorectal malignancy is often suggeste by a history of gradual weight loss intermittent blood in the stools altered bowel habits,Diagnostic approach to GI blee

21、ding,Hemorrhoidal bleeding is often suggested by the presence of bright red blood surrounding well-formed,normal-appearing stools.,Diagnostic approach to GI bleeding,Patients with stigmata(特征)of chronic liver disease e.g.,spider angioma(蜘蛛痣),ascites(腹水),gynecomastia(男性乳房发育)and upper GI bleeding ofte

22、n bleed from esophageal varices or erosion(糜烂).,Diagnostic approach to GI bleeding,Localized epigastric tenderness(触痛)to palpation may indicate peptic ulcer disease or gastritis.,Diagnostic approach to GI bleeding,Occasionally patients with lower GI tract bleeding from a malignancy have a palpable l

23、ower abdominal mass,hepatomegaly(肝肿大)，signs of obvious weight loss.,Diagnostic approach to GI bleeding,A rectal examination is essen-tial to document stool color as well as to palpate for gross ano-rectal(肛直肠)mass lesions such as polyps,cancers,or large hemorrhoids.,Diagnostic approach to GI bleedin

24、g,Endoscopy(内镜)Endoscopy is the diagnostic procedure of choice because of its high accuracy and immediatetherapeutic potential.Endoscopy,however,must be Performed only following adequate resuscita-tion(复苏).,Diagnostic approach to GI bleeding,EndoscopyContraindications：acute myocardial infarction sev

25、ere chronic lung disease hemodynamic instabilitypatient agitation(焦虑不安)terminal malignancy,Diagnostic approach to GI bleeding,Barium radiography(钡餐)Barium radiography is noninvasivebut has significant disadvantages,particularly in patients who are bleeding briskly(actively).,Diagnostic approach to G

26、I bleeding,Angiography(血管造影)Angiography may localize the site of bleeding.,Diagnostic approach to GI bleeding,Angiography Bleeding must be active because angiography detects only extravasation(外渗)of contrast(造影剂)into the GI tract.,思考题：,胃肠道出血有哪些表现形式？胃肠道出血的病因有哪些？对胃肠道出血的诊断通常采用哪些方式？,References：Textbook of physical diagnosis.4th edition.MH Swartz.Elsevier science.2002.Sleisenger&Fordtrans Gastrointestinal and liver disease.6th edition.M Feldman,BF Scharschmidt,MH Sleisenger.W.B.Saunders,2001.physical Diagnosis，Fourth Edition,Jo-Ann Reteguiz,M.D.,McGraw-Hill,