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1、Yang-Chang WuProfessorCONTACT INFORMATION:ProfessorYang-Chang Wu (Mr.), (Eric Wu)100 shih Chuan 1st RD., Kaohsiung 807, TaiwanGraduate institute of Natural Products,Kaohsiung Medical UniversityTEL/FAX: +886-7-3114773E-mail: yachwukmu.edu.twEDUCATION:19971999- EMBA in Medical Agents Management, Sun Y

2、et-Sen University,Kaohsiung19871987- Postdoctoral fellow with Professor Kuo-Hsiung Lee, University of North Carolina at Chapel Hill, U.S.A.19861987- Postdoctoral fellow with Professor Yoshimasa Hirata, Meijo University,Japan19821986- Doctor of Philosophy, Kaohsiung Medical University, Taiwan19791982

3、- Master of Science, Kaohsiung Medical University, Taiwan19711975- B.S. in Pharmacy, Kaohsiung Medical University, TaiwanWORKING EXPERIENCE:1992.08- Professor and Director of Graduate Institute of Natural Products (KMU)1990.08- Adjunct Professor of Department of Marine Resources, Sun Yet-Sen Univers

4、ity.1990.08- Professor of School of Pharmacy (KMU)1986.081990.07- Associate Professor of School of Pharmacy (KMU)1982.081986.07- Instructor of School Pharmacy (KMU)1977.081982.07- Teaching Assistant of School of Pharmacy (KMU)RESEARCH INTERESTS:l Anticancer, Anti-HIV, Anti-SARS, Anti-inflammatory, C

5、ardiovascular Natural Products from Taiwanese Medicinal Plants and Marine Resources, and Oriental Herbal Medicine (Including Traditional Chinese Medicine)l Synthetic and Semi-synthetic Natural Products Derivatives of Antitumor, Anti-Platelet Aggregation, Anti-inflammatory, and Other Pharmacological

6、Activity. l Studies on groups of compounds related to Annonaceous acetogenins, alkaloids, and terpenenoids etc.PUBLICATIONS (within five years)1. Keh-Shaw Chen and Yang-Chang Wu*, 1999, “Sesquiterpenoids from Neolitsea parvigemma: Isolation, Oxidation Products and Antiplatelet Actions.”, Tetrahedron

7、., 55, 1353-1366. (SCI) 2. Jacek Gawronski and Yang-Chang Wu*, 1999, “A Note on the Determination of Absolute Configuration of Acetogenins by Circular Dichroism.”, Polish Journal of Chemistry.,73, 241-243. (SCI)3. Shih-Hung Tsai, Pei-Chen Hsieh, Li-Lan Wei, Feui-Fen Chiu, Yang-Chang Wu and Ming-Jung

8、 Wu, 1999, “Synthesis of a Hydroxylated Muricatacin Analog Related to Squamocin.”, Tetrahedron Lett., 40, 1975-1976. (SCI) 4. Chung-Yi Chen, Fang-Rong Chang, Feui-Fen Chiu, Ming-Jung Wu and Yang-Chang Wu*, 1999, ”Aromin-A, a New Annonaceous Acetogenin from Annona cherimola.”, Phytochemistry, 51, 429

9、-433. (SCI)5. Chung-Yi Chen, Fang-Rong Chang and Yang-Chang Wu*, 1999, “Cheritamine, a New N-Fatty Acyl Tryamine and Other Constituents from the Stems of Annona cherimola.”, J. Chin. Chem. Soc., 46, 77-86. (SCI) 6. Tian-Jye Hsieh, Fang-Rong Chang and Yang-Chang Wu*, 1999, “The Constituents from Cana

10、nga odorata.”, J. Chin. Chem. Soc., 46, 607-611. (SCI)7. Keh-Shaw Chen, Fang-Rong Chang, Michael-Y Chiang and Yang-Chang Wu*, 1999, “Oxidation products of Zeylanidine.”, J. Nat. Prod., 62, 622-625. (SCI) 8. Fang-Rong Chang, Jien-Lin Chen, Feui-Fen Chiu, Ming-Jung Wu and Yang-Chang Wu*, 1999, “Bioact

11、ive Acetogenins from the Seeds of Annona artemoya.”, Phytochemistry, 51, 883-889. (SCI) 9. Hang-Ching Lin, Hsiou-Yu Ding, Feng-Nien Ko, Che-Ming Teng and Yang-Chang Wu*, 1999, “Antiplatelet Aggregation Priniciples from Paeonia Species.”, Planta Medica, 65, 595-599. (SCI)10. Hsiou-Yu Ding, Yang-Chang

12、 Wu, Hang-Ching Lin, Yu-Yi Chan, Pei-Lin Wu and Tian-Shung Wu, 1999, “Glycosides from Paeonia suffruticosa”, Chem. Pharm. Bull., 47, 652-655. (SCI)11. Yi-Chen Chia, Fang-Rong Chang and Yang-Chang Wu*, 1999, “Fissohamione, a Novel Furanone from Fissistigma oldhamii”, Tetrahedron Lett., 40, 7513-7514.

13、 (SCI) 12. Tian-Jye Hsieh, Chung-Yi Chen, Reen-Yen Kuo, Fang-Rong Chang and Yang-Chang Wu*, 1999, “Two New Alkaloids from Artabotrys uncinatus.”, J. Nat. Prod., 62, 1192-1193 . (SCI) 13. Chih-Chuang Liaw, Fang-Rong Chang and Yang-Chang Wu*, 1999, “New Annonaceous Acetogenins from Rollinia mucosa Bai

14、ll.”, J. Nat. Prod., 62, 1613-1617. (SCI) 14. Yi-Chen Chia, Keh-Shaw Chen, Che-Ming Teng and Yang-Chang Wu*, 1999, “Antiplatelet Actions of Aporphinoids from Formosan Plants.”, Bioorg. Med. Chem. Lett., 9, 3295-3300. (SCI) 15. Hsiou-Yu Ding, Yang-Chang Wu, Hang-Ching Lin, 1999,“Reassignment of Chimi

15、cal Shifts of Atractylodin and Acetylatractylodinol from Atractylodes chinensis., Chin. Pharm. J., 51, 359-363.16. Keh-Shaw Chen, Che-Ming Teng, Chieh-Fu Chen and Yang-Chang Wu*, 2000, “Furoquinolines with Antiplatelet Aggregation Activity from Leaves of Melicope confusa.”, Planta Medica,66,80-81. (

16、SCI)17. Yuh-Chwen Chang, Fang-Rong Chang and Yang-Chang Wu*, 2000, “The Constituents of Lindera glauca”, J. Chin. Chem. Soc., 47, 373-380. (SCI) 18. Yi-Chen Chia, Jin-Bin Wu and Yang-Chang Wu*, 2000, “Two Novel Cyclopentenones from Fissistigma oldhamii.”, Tetrahedron Lett., 41, 2199-2201. (SCI)19. W

17、en-Bin Pan, Fang-Rong Chang and Yang-Chang Wu*, 2000, “Tupichigenin A, a Novel Steroidal Sapogenins from Tupistra chinensis.”, J. Nat. Prod., 63,861-863. (SCI)20. Fang-Rong Chang, Chung-Yi Chen, Po-Hsun Wu, Reen-Yen Kuo, Yuh-Chwen Chang and Yang-Chang Wu*, 2000, “New Alkaloids from Annona purpurea.”

18、, J. Nat. Prod., 63,746-748. (SCI) 21. Chung-Yi Chen, Fang-Rong Chang, Chun-Ping Cho and Yang-Chang Wu*, 2000, “Ent-Kaurane Diterpenoids from Annona glabra.”, J. Nat. Prod., 63,1000-1003. (SCI) 22. Hui-Chi Huang, Chien-Chang Shen, Chieh-Fu Chen, Yang-Chang Wu* and Yao-Haur Kuo, 2000, “A Novel Agarof

19、uran Sequiterpene, Celahin D from Celastrus hindsii Benth.”, Chem. Pharm. Bull., 48,1079-1080. (SCI)23. Hsiou-Yu. Ding, Yang-Chang Wu* and Hang-Ching Lin, 2000, “Phytochemical and Pharmacological Studies on Chinese Changzhu.”, J. Chin. Chem. Soc., 47,561-566. (SCI).24. Hsiou-Yu Ding, Hang-Ching. Lin

20、, Che-Ming Teng and Yang-Chang Wu*, 2000, ”Phytochemical and Pharmacological Studies on Chinese Paeonia Species.”, J. Chin. Chem. Soc.,47,381-388. (SCI)25. Hang-Ching Lin, Hsiou-Yu. Ding and Yang-Chang Wu*, 2000, ”No Effect of Aromatic acid from Paeonia Species on Thrombin Activity Involed in Fibrin

21、 Formation.”, Chin. Pharm. J., 52, 189-194.26. Yi-Chen Chia, Fang-Rong Chang, Che-Ming Teng and Yang-Chang Wu*, 2000, “Aristolactams and Dioxoaporphines from Fissistigma balansae and F. oldhamii.”, J. Nat. Prod., 63,1160-1163. (SCI)27. Fang-Rong Chang, Chung-Yi Chen, Tian-Jye Hsieh, Chun-Ping Cho an

22、d Yang-Chang Wu*, 2000, “Chemical Constituents from Annona glabra III., J. Chin. Chem. Soc.,47, 913-920. (SCI)28. Wen-Bin Pan, Fang-Rong Chang and Yang-Chang Wu*, 2000, “Spirostanol Sapogenins from the Underground Parts of Tupistra chinensis., Chem. Pharm. Bull., 48,1350-1353. (SCI)29. Chung-Yi Chen

23、, Fang-Rong Chang, Yao-Ching Shih, Tian-Jye Hsieh, Yi-Chen Chia, Huang-Yi Tseng, Hua-Chien Chen, Shu-Jen Chen, Ming-Chu Hsu and Yang-Chang Wu*, 2000, “ Cytotoxic Constituents of Polyalthia longifolia var. pendula.”, J. Nat. Prod., 63, 1475-1478. (SCI)30. Wen-Li Lo, Fang-Rong Chang and Yang-Chang Wu*

24、, 2000, “Alkaloids from the Leaves of Fissistigma glaucescens.”, J. Chin. Chem. Soc., 47, 1251-1256. (SCI)31. Chung-Yi Chen, Fang-Rong Chang, Wen-Bin Pan and Yang-Chang Wu*, 2001, “Four Alkaloids from Annona cherimola.”, Phytochemistry, 56, 753-757. (SCI)32. Reen-Yen Kuo, Fang-Rong Chang, Chung-Yi C

25、hen, Che-Ming Teng, Hsin-Fu Yen and Yang-Chang Wu*, 2001, “Antiplatelet Activity of N-(Methoxycarbonyl) Aporphines from Rollinia mucosa.”, Phytochemistry, 57, 421-425. (SCI)33. Tian-Jye Hsieh, Fang-Rong Chang, Yi-Chen Chia, Chung-Yi Chen, Huey-Fen Chiu and Yang-Chang Wu*, 2001,” Cytotoxic Constituen

26、ts of Cananga odorata.”, J. Nat. Prod., 64,616-619. (SCI)34. Fang-Rong Chang and Yang-Chang Wu*, 2001,” Novel Cytotoxic Annonaceous Acetogenins from Annona muricata.”, J. Nat. Prod., 64,925-931. (SCI)35. Ramesh Patnam, Fang-Rong Chang, Chung-Yi Chen, Reen-Yen Kuo, Yue-Han Lee and Yang-Chang Wu*, 200

27、1, “Hydrachine A, a Novel Alkaloids from the roots of Hydrangea chinensis.”, J. Nat. Prod., 64,948-949. (SCI)36. Tian-Jye Hsieh, Fang-Rong Chang, Yi-Chen Chia, Chung-Yi Chen, Hang-Ching Lin, Huey-Fen Chiu and Yang-Chang Wu*, 2001,” The Alkaloids of Artabotrys uncinatus.”, J. Nat. Prod., 64,1157-1161

28、. (SCI)37. Hwa-Woei Chih, Hui-Fen Chiu, Kung-Sung Tang, Fang-Rong Chang and Yang-Chang Wu, 2001,”Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction.” Life Sciences, 69, 1321-1331.38. Yuh-Chwen Chang, Chung-Yi

29、 Chen, Fang-Rong Chang, and Yang-Chang Wu*, 2001,” Alkaloids from Lindera glauca”, J. Chin. Chem. Soc., 48,811-815. (SCI)39. Chung-Yi Chen, Yang-Chung Wu, 2001, ”Annocherine C, A New C-Hydroxy Benzylisoquinolide and Other constituents from the Leaves of Annona cherimola.”, J. Chin. Chem. Soc., 48,12

30、03-1206. (SCI)40. Reen-Yen Kuo, Fang-Rong Chang, and Yang-Chang Wu*,2001,“A new propentdyopent derivative, rollipyrrole, from Rollinia mucosa Baill.” Tetrahedron Lett.,42,7907-7909. (SCI)41. Kuo-Chu Chang, Ming-Jai Su, Ying-I Peng, Ching-Chih Shao, Yang-Chang Wu and Yung-Zu Tseng, 2001, “Mechanical

31、effwcts of liriodenine on the left ventricular-arterial coupling in Wister rats: pressure-stroke colume analysis.”, British Journal of Pharmacology, 133, 29-36. (SCI)42. Tian-Shung Wu, Li-Shian, Ping-Chung Kuo, Yann-Lii Leu, Meei-Jen Liou, Pei-Lin Wu, Yang-Chang Wu, Song-Chou Iou, Yuh-Pan Chen and H

32、sien-Chang Chang, 2001, “Cytotoxic Principles from the Leaves of Tithonia diversifolia.”, The Chinese Pharmaceutical Journal, 53, 217-223.43. Wen-Li Lo, Fang-Rong Chang, Chih-Chuang Liaw and Yang-Chang Wu*, 2002, ” Cytotoxic Coumaronochromones from Roots of Euchresta formosana.”, Planta Medica, 68,

33、146-151. (SCI)44. Fang-Rong Chang, Tian-Jye Hsieh, Ti-Lung Huang, Chung-Yi Chen, Reen-Yen Kuo, Yuh-Chwen Chang, Hui-Fen Chiu and Yang-Chang Wu*, 2002, ” Cytotoxic Constituents of the Stem Bark of Neolitsea acuminatissima ”, J. Nat. Prod., 65, 255-258. (SCI)45. Chih-Chuang Liaw, Fang-Rong Chang, Chih

34、-Yuan Lin, Chi-Jung Chou, Hui-Fen Chiu, Ming-Jung Wu, and Yang-Chang Wu*, 2002, ” New Cytotoxic Monotetrahydrofuran Annonaceous Acetogenins from Annona muricata.”, J. Nat. Prod., 65, 470-475. (SCI)46. Reen-Yen Kuo, Fang-Rong Chang, and Yang-Chang Wu*, 2002, ” Chemical Constituents and Their Pharmaco

35、logical Activities from Formosan Annonaceous Plants.”, The Chinese Pharmaceutical Journal, 54, 155-173.47. Wen-Li Lo, Fang-Rong Chang, and Yang-Chang Wu*, 2002, ” Coumaronochromones and flavanones from Euchresta formosana roots”, Phytochemistry, 60, 839-845. (SCI)48. Wen-Li Lo, Fang-Rong Chang, Tian

36、-Jye Hsich and Yang-Chang Wu*, 2002, ” The Constituents of Euchresta formosana .”, J. Chin. Chem. Soc., 49, 421-426. (SCI)49. Ramesh Patnam, Fang-Rong Chang, Reen-Yen Kuo, Wen-Bin Pan and Yang-Chang Wu* 2002, ” Microwave Enhanced Acetylation of Alcohols.”, J.Chem. Res-S., 301-302. (SCI) 50. Shyng-Sh

37、iou F. Yuan, Hsueh-Ling Chang, Ming-Feng Hou, Te-Fu Chan, Ying-Hsien Kao, Yang-Chang Wu and Jinu-Huang Su, 2002, ” Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism”, Toxicology, 177, 123-130. (SCI)51. Yu-Liang Yang, Fang-Rong Chang, Chin

38、-Chung Wu, Wei-Ya Wang, Yang-Chang Wu*, 2002, “ New ent-Kaurane Diterpenoids with Anti-platelet aggregation activity from Annona squamosa”, J. Nat. Prod., 65, 1462-1467. (SCI)52. Yang-Chang Wu, Jen-Hao Hsu, I-Min Liu, Shorong-Shii Liou, Hui-Chen Su, Juei-Tang Chang, 2002, “Increase of insulin sensit

39、ivity in diabetic rats received Die-Huang-wan, a herbal mixture used in Chinese traditional medicine.”, Acta Pharmacologica Sinica, 23, 1181-1187. (SCI) 53. Sheng-Nan Wu, Hung-Ting Chiang, Fang-Rong Chang, Chih-Chuang Liaw and Yang-Chang Wu , 2003, “Stimulatory Effects of Squamocin, an Annonaceous A

40、cetogenin, on Ca2+-Activated K+ Current in Cultured Smooth Muscle Cells of Human Coronary Artery.”, Chemical Research in Toxicology., 16, 15-22.54. Yu-Liang Yang, Fang-Rong Chang, Yang-Chang Wu*, 2003, “ Total Synthesis of 3,4-Dihydrobenzohquinazolin-4-one and Structural Elucidation of Perlolidine a

41、nd Samoquasine A”, Tetrahedron Lett., 44, 319-322. (SCI)55. Wen-Bin Pan, Fang-Rong Chang, Li-Mei Wei, Ming-Jung Wu, and Yang-Chang Wu*, 2003, “New and Efficient Method for esterification of Carboxylic Acids with Simple Primary and Secondary Alcohols Using Cerium (IV) Ammonium Nitrate (CAN ”, Tetrahe

42、dron Lett., 44, 331-334. (SCI)56. Wen-Bin Pan, Fang-Rong Chang, Li-Mei Wei, Yang-Chang Wu*, 2003, “New Flavans, Spirostanol Sapogenins, and a Pregnane Genin from Tupistra chinensis and Their Cytotoxicity”, J. Nat. Prod., 66, 161-168. (SCI)57. Ashraf Taha Khalil, Fang-Rong Chang, Yue-Han Lee, Chung-Y

43、i Chen, Chih-Chuang Liaw, Patnam Ramesh, Shyng-Shiou F. Yuan, Yang-Chang Wu*, 2003, “ Chemical Constituents from the Hydrangea chinensis”, Archives of Pharmacal Research, 26,15-20. (SCI)58. Reen-Yen Kuo, Chin-Chung Wu, Fang-Rong Chang, Jwu-Lai Yeh, Ing-Jun Chen, and Yang-Chang Wu,* 2003, “Antiplatel

44、et Activity of Synthetic Pyrrolo-benzylisoquinolines”, Bioorg. Med. Chem. Lett., 13, 821-823. (SCI)59. Chih-Chuang Liaw, Fang-Rong Chang, Ming-Jung Wu, and Yang-Chang Wu*, 2003,“A Novel Constituent from Rollinia mucosa, Rollicosin, and A New Approach to Develop annonaceous Acetogenins as Anti-tumor

45、Agents.”, J. Nat. Prod., 66, 279-281. (SCI)60. Wen-Li Lo, Chin-Chung Wu, Fang-Rong Chang, Wei-Ya Wang, Ashraf Taha Khail, Kuo-Hsiung Lee and Yang-Chang Wu*, 2003, ” Antiplatelet and Anti-HIV Effects of Constituents From Euchresta formosana”, Nat. Prod. Res. (Nat. Prod. Lett.), 17 (2), 91-97. (SCI)61

46、. Hui-Fen Chiu, Tsai-Tung Chih, Yun-Mei Hsian, Chih-Hua Tseng, Ming-jung Wu and Yang-Chang Wu., 2003, “Bullatacin, a potent antiumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells.”, Biochemical Pharmacology, 65,319-

47、327.62. Pei-Wen Hsieh, Fang-Rong Chang, Shing-Fu Yen and Yang-Chang Wu*, 2003, ” Anemonine and norsesquiterpenes from Drymaria diandra”, Biochem. Sys. Ecol., 31, 541-543. (SCI)63. Yuh-Chwen Chang, Pei-Wen Hsieh, Fang-Rong Chang, Ru-Rong Wu, Kuo-Hsiung Lee, Yang-Chang Wu*, 2003, “ Two New Protopines

48、Argemexicaines A and B and the Anti-HIV Alkaloid, 6-Acetonyldihydrocherythrine, from Formosan Argemone mexicana”, Planta Medica, 69,148-152. (SCI)64. Shyng-Shiou Yuan, Ming-Feng Hou, Hsueh-Ling Chang, Te-Fu Chan, Ying-Hsien Wu, Yang-Chang Wu and Jinu-Huang Su, 2003, ” Arsenic-induced nitric oxide ge

49、neration is cell cycle-dependent and aberrant in NBS cells”, Toxicology In Vitro, 17, 139-143. (SCI)65. Yu-Hsuan Lan, Fang-Rong Chang, Jin-Hsien Yu, Yang-Chang Wu*, 2003, “New Cytotoxic Styrylpyrones from Goniothalamus amuyon”, J. Nat. Prod., 66, 487-490. (SCI)66. Yao-Haur Kuo,* Hui-Chi Huang, Wen-Fei Chiou, Li-Shian Shi, Tia