新生儿坏死性小肠结肠炎课件.pptx

《新生儿坏死性小肠结肠炎课件.pptx》由会员分享，可在线阅读，更多相关《新生儿坏死性小肠结肠炎课件.pptx（16页珍藏版）》请在三一办公上搜索。

1、Neonatal necrotizing enterocolitis,Kunyao Yu,Outline,Risk factorBacterial&NECIntestinal defense mechanismClinical presentation Bells stageTreatment,Risk Factor,PrematureLow birth weight(1500g)Broad-spectrum antibioticsFeeding,Bacterial&NEC,Intestinal bacterial colonization in the infant-Delivery met

2、hod-Feeding,Intestinal defense mechanism,PeristalsisGastric acidProteolytic enzymesIntestinal mucusCell surface glycoconjugatesCells tight junctionsImmunology,Clinical presentation,Abdominal sign:distension,vomiting,hematocheziaFeeding intoleranceLethargyTemperature instabilityHypotension,Image,Bell

3、s stage,Treatment,Stage Ia:-NPOStage Ib-IIb/IIIa:-NPO-Broad spectrum antiboticsStage IIIa-IIIb:-Surgery/Peritoneal drain,Probiotics-treat?,Probiotics-treat?,What is the optimal probiotic organism(s)?What is the optimal administration including assessment of what patients are the best candidates for treatment?What is the optimal probiotic dose?What is the best timing of administration?What is the most efcacious length of treatment?,THANK YOU,