心房颤动机制研究进展细胞核孔复合物与跨核运输课件.ppt
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1、心房颤动机制研究进展-细胞核孔复合物与跨核运输障碍,故事的开始:常染色体隐性遗传房颤家系,-57 family members-32 males-25 females-5 living generations-Age: 3 m-93 y-Autosomal recessive inheritance pattern-7 consanguineous marriages,An Interesting Family,Circulation, 2004,Oberti et al. Circulation, 2004;110:3753-3759,Proband V:11 -Chronic AF-QTc
2、=0.42 s-Delivered by caesarean section due to fetal tachycardia, HR of 250 bpm, atrial fibrillation and atrial flutter-Echo at day 2: marked dilatation of both atria, EF 52%-EP at 1 m detected AF, ablation of AV node-Pacemaker Echo at 2 m: mild atrial dilatation, normal EF 52%-Died suddenly at 15 m,
3、Oberti et al. Circulation, 2004;110:3753-3759,Patient VI:2 -Chronic AF-QTc=0.40 s-HR=125 bpm with digoxin and propafenoneEcho at 15 m: normal-Died suddenly at 19 m,Oberti et al. Circulation, 2004;110:3753-3759,Patient V:9 -Atrial flutter- Delivered by C section due to fetal tachycardia-Born with sup
4、raventricular tachycardia-ECG at 24 d: atrial flutter, HR=200 bpm-Echo at 24 d: normal-Later Echo: mild dilatation of left ventricle and left atria-Died suddenly at 3 m,Oberti et al. Circulation, 2004;110:3753-3759,Patient V:10 -Born with atrial tachycardia-Echo : normal-Died suddenly at 2 m,Patient
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