急性肾炎专题知识讲座培训课件.ppt

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1、急性肾炎专题知识讲座,急性肾炎专题知识讲座,Edema,急性肾炎专题知识讲座,2,Edema 急性肾炎专题知识讲座2,Hematuria,急性肾炎专题知识讲座,3,Hematuria急性肾炎专题知识讲座3,HypertensionConvulsion Anti o C3,proteinuria,急性肾炎专题知识讲座,4,Hypertension急性肾炎专题知识讲座4,This glomerulus is hypercellular and capillary loops are poorly defined. This is a type of proliferative glomerulon

2、ephritis,急性肾炎专题知识讲座,5,急性肾炎专题知识讲座5,the immune deposits are distributed in the capillary loops in a granular, bumpy pattern because of the focal nature of the deposition process,急性肾炎专题知识讲座,6,the immune deposits are distri,Diagonosis? Why?,edema proteinuriaHematuriahypertension.,急性肾炎专题知识讲座,7,Diagonosis

3、? Why?,急性肾炎专题知识讲座培训课件,Background,Atypical onsetedema hematuria proteinuria hypertension Persistently depressed C3 (past 8-10 wk),急性肾炎专题知识讲座,9,BackgroundAtypical onset急性肾炎专,急性肾炎专题知识讲座,10,急性肾炎专题知识讲座10,Pathophysiology and Clinical manifestation,急性肾炎专题知识讲座,11,Pathophysiology and Clinical m,streptococcal

4、 antigens specific antibodies activate the complement system c3 ,急性肾炎专题知识讲座,12,急性肾炎专题知识讲座12,急性肾炎专题知识讲座,13,急性肾炎专题知识讲座13,Various cytokines other cellular immunity factors glomerular basement membrane blood efusion Hematuria Proteinuria cast,急性肾炎专题知识讲座,14,Various cytokines 急性肾炎专题知识讲座14,急性肾炎专题知识讲座,15,急性

5、肾炎专题知识讲座15,Various cytokines proliferation of mesangial and epithelial cells glomerular perfusion ,glomerular filtrate (GF)- Severe oliguria, renal failure,急性肾炎专题知识讲座,16,Various cytokines proliferati,急性肾炎专题知识讲座,17,急性肾炎专题知识讲座17,glomerular filtrate (GF)- H2O,Na+ sterve -blood volume edema hypertention

6、 circulatory congestionencephalopathy.,急性肾炎专题知识讲座,18,glomerular filtrate (GF)-,Pathology,The hypercellularity of post-streptococcal glomerulonephritis is due to increased numbers of epithelial, endothelial, and mesangial cells as well as neutrophils in and around the capillary loops. This disease ma

7、y follow several weeks after infection with certain strains of group A beta hemolytic streptococci.,急性肾炎专题知识讲座,19,PathologyThe hypercellularity,Post-streptococcal glomerulonephritis is immunologically mediated, and the immune deposits are distributed in the capillary loops in a granular, bumpy patte

8、rn because of the focal nature of the deposition process.,急性肾炎专题知识讲座,20,Post-streptococcal glomerulone,Clinical manifestion,Sex Age HistoryGross hematuriaedema Hypertension,急性肾炎专题知识讲座,21,Clinical manifestion Sex Ag,1 Circulatory congestion2 Hypertensive encephalopathy 3 Acute renal failure,急性肾炎专题知识讲座,22,急性肾炎专题知识讲座22,