干细胞治疗自身免疫性疾病课件.ppt
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1、UB-MSC: the new gold standard to treat several human diseases, especially autoimmune diseases,Institute of Clinical Medicine, Renmin Hospital, Hubei University of Medicine,Junming Tang2015.8,2020/11/3,1,UB-MSC: the new gold standard,Outline,一、Definition二、Characteristics三、Classification四、Pathogenesis
2、五、Traditional therapy六、Biotherapy(antibody、vaccine、gene therapy ) 七、Cell therapy(DC、HSC、MSC),2020/11/3,2,Outline一、Definition2020/11/32,一、Definition,Autoimmunity refer to the immune responses to self cells or self components.Autoimmune disease refer to the disease state resulted from immune responses
3、 directed against self cells or self components.,2020/11/3,3,一、Definition Autoimmunity refe,二、Characteristics,Autoimmune antibody and (or) autoreactive T lymphocyte can be detected.Autoimmune antibody and (or) autoreactive T lymphocyte mediate immune response which lead to damage or functional distu
4、rbanceThe turnover of pathogenetic condition relate with autoimmune response intensityRecurrent attacks and chronic,2020/11/3,4,二、Characteristics Autoimmune a,三、Classification,Organ-specific autoimmune disease Graves disease、insulin-dependent diabetes mellitusSystemic autoimmune disease systemic lup
5、us erythematosus,2020/11/3,5,三、ClassificationOrgan-specific,四、Pathogenesis,Autoimmune antibodyDisfunction immunologic system(autoreactive T lymphocyte)Genetics and endocrine,2020/11/3,6,四、PathogenesisAutoimmune antib,Examples of Human Autoimmune Diseases with Possible Molecular Mimicry as a Mechanis
6、m,Clin Rev Allergy Immunol. 2012; 42(1): 102C11,2020/11/3,7,Examples of Human Autoimmune D,常见自身免疫病,2020/11/3,8,类别病名自身抗原非器官特异性系统性红斑狼疮胞核成分(D,五、Traditional therapy,General therapyCortisoneImmune inhibitorsOthers,2020/11/3,9,五、Traditional therapyGeneral t,六、Biotherapy,AntibodyVaccine,Pharmaceutical Biot
7、echnology 2012, 19( 4) : 364 368. ChineseJournalofNewDrugs2011, 20(8),2020/11/3,10,六、BiotherapyAntibodyPharmaceut,How to better solve the suffering of patients,New ways,2020/11/3,11,How to better solve the suf,七、Gene and Cell therapy,DC、NK、CIK、B、T、LAKStem cells(HSC、MSC.),2020/11/3,12,七、Gene and Cell
8、 therapyDC、NK、C,八、Stem Cell therapy for AID,1.Definition & Historic landmarks 2.Cell types: MSC origin and 3.Cell harvest, culture and store4.Delivery method5.Comparative Evaluation6.Animal experimental7.Mechanism8. Clinical experimental 9.Conclusion,2020/11/3,13,八、Stem Cell therapy for AID1.D,1.Ste
9、m cells,2020/11/3,14,1.Stem cells2020/11/314,15,Historic landmarks in the field of stem cell biology,Circ Res. 2014;114:21-27.),2020/11/3,15,15Historic landmarks in the fi,2.Cell types,16,2020/11/3,16,2.Cell types162020/11/316,MSC: origin and biological traits,Csar Nombela-Arrieta,Nature Reviews Mol
10、ecular Cell Biology 12, 126-131 (2011),Synovium,Cartilage,Dental pulp,Bone marrow,Kidney,Pancreas,Adipose tissue,Muscle,Brain,liver,Tonsil,Placenta,Umbilical Cord,Thymus,Pericytes,Amniotic fluid,2020/11/3,17,MSC: origin and biological tra,3.Isolation, culture store of mesenchymal stem cells from Wha
11、rtons jelly,J. Biomedical Science and Engineering, 2012, 5, 580-586,Cryobiology. 2014 Jun;68(3):467-72.,Current Stem Cell Research & Therapy, 2013, 8, 144-155,2020/11/3,18,3.Isolation, culture store of,4.Delivery methods,PMID: 26068030,2020/11/3,19,4.Delivery methodsPMID: 260680,5.Comparative Evalua
12、tion of different MSCs,J Immunol Res. 2015:394917.,2020/11/3,20,5.Comparative Evaluation of di,The advantages of UB-MSCs,Stem Cells International, 2013,246134,2020/11/3,21,The advantages of UB-MSCsStem,Table 1: Phenotypic pro WJ-MSCs compared to MSCs from other sources,2020/11/3,22,Table 1: Phenotyp
13、ic pro WJ-MSC,Table 2: Transcriptomic pro WJ-MSCs compared to MSCs from other sources,2020/11/3,23,Table 2: Transcriptomic pro WJ,Table 2: Transcriptomic pro WJ-MSCs compared to MSCs from other sources,2020/11/3,24,Table 2: Transcriptomic pro WJ,The differentiation advantages of WJ-MSCs compared to
14、MSCs from other sources,Tissue Eng Part B Rev. 2014 Oct;20(5):523-44.,2020/11/3,25,The differentiation advantages,Better: autologous/allogenic?,Allogenic healthy BM-MSC, UB-MSC,Cellular Immunology 293 (2015) 113121,2020/11/3,26,Better: autologous/allogenic?A,Summary,.,1.Umbilical cord derived MSCs a
15、re more primitive, proliferative, regenerative, homing and immuno-suppressive than their adult counterparts2.Healthy UB-MSC is better than MSC from patient-self,2020/11/3,27,Summary . 1.Umbilical cord der,6.Preclinical Efficacy and Mechanisms of Mesenchymal Stem Cells in Animal Models of Autoimmune
16、Diseases,Immune Network 2014;14(2):81-88,2020/11/3,28,6.Preclinical Efficacy and Mec,7.Mesenchymal stem cell immunosuppression of innate/adaptive immune cells,World J Stem Cells 2014; 6(5): 526-539,2020/11/3,29,7.Mesenchymal stem cell immuno,Differential toll-like receptor stimulation affects mesenc
17、hymal stem cell immune-modulation,2020/11/3,30,Differential toll-like recepto,Summary,Immunosuppression,2020/11/3,31,SummaryImmunosuppression2020/1,Permit for application of UB-MSC in human AID,CellStemCell 17,July2,2015,2020/11/3,32,Permit for application of UB-,8.Clinical trails: Stem cell for AID
18、,2020/11/3,33,8.Clinical trails: Stem cell f,Clinical trials (registered as of Aug.8 2015 ) using HSC,haematologica | 2010; 95(2):184-193.,2020/11/3,34,Clinical trials (registered as,Clinical trials (registered ) using MSC During HSC transplantation,Maria Ester Bernardo, Immunology Letters,Available
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