化脓性脑膜炎英文版培训课件.ppt

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1、化脓性脑膜炎英文版,化脓性脑膜炎英文版,Acute infection of central nervous system(CNS). 90% of cases occur in the age of 1mo-5yr. The inflammation of meninges caused by various bacteria.Common features in clinical practices include: fever, increased intracranial pressure, meningeal irritation. One of the most potential

2、ly serious infections, associated with high mortality (about 10%) and morbidity.,Purulent Meningitis,化脓性脑膜炎英文版,2,Acute infection of central ne,Etiology1.1 Pathogens:Main pathogens: Neissria meningitidis, streptoccus pneumoniae, Haemophilus influenzae. (2/3 of purulent meningitis are caused by these

3、pathogens)Pathogens in special populations (neonate & 3mo infants , malnutrition, immunodeficiency): gramnegative enteric bacilli, group B streptococci, staphlococcus aureus,化脓性脑膜炎英文版,3,Etiology化脓性脑膜炎英文版3,1.2 Major risk factors for meningitis Immature immunologic function and attenuated immunologic

4、response to pathogens Low level of immunoglobulin, defects of complement and properdin system Immature or impaired blood-brain-barrier (BBB) Immature BBB function: maturation at about 1yr Impaired BBB: Congenial or acquired defects across mucocutaneous barrier,化脓性脑膜炎英文版,4,1.2 Major risk factors for

5、me,1.3 Access of bacteria invasion Typical access-hematogenous dissemination Bacteria colonizing the mucous membranes of the nasopharynx invasion into local tissue bacteremia hematogenous seeding to the subarachnoid space Mode of transmission: Person to person contact through respiratory tract secre

6、tions or droplets,化脓性脑膜炎英文版,5,1.3 Access of bacteria invas,Bacteria spread to the meninges directly: through anatomic defects in the skull or head trauma Invasion from parameningeal organs: such as paranasal sinuses or middle ear,Access of bacteria invasion,化脓性脑膜炎英文版,6,Bacteria spread to the mening,

7、2. Pathology Structure of meninges,化脓性脑膜炎英文版,7,2. Pathology化脓性脑膜炎英文版7,Characterized by leptomeningeal and perivascular infiltration with polymorphonuclear leukocytes and an inflammatory exudate.Exudate which may be distributed from convexity of brain to basal region of cranium. Exudate is more thick

8、ness due to streptococcus pneumoniae than other pathogens.,Pathology,化脓性脑膜炎英文版,8,Characterized by leptomeninge,3. Clinical manifestations The younger the child is, the higher incidence of meningitis will be. -2/3 of cases occur less than 1yr of age. Mode of presentation: Acute or fulminant onset: sy

9、mptoms and signs of sepsis; meningitis evolve rapidly over a few hours and death within 24 hours; usually infected with Neissria meningitides (N. meningitides).,化脓性脑膜炎英文版,9,3. Clinical manifestations化脓性脑,Subacute onset: Precede by several days of upper respiratory tract or gastrointestinal symptoms;

10、 difficult to pinpoint the exact onset of meningitis; usually with meningitis due to Haemophilus influenzae (H influenzae) and streptoccus pneumococcus (S pneumococcus).,Mode of presentation,化脓性脑膜炎英文版,10,Subacute onset: Mode of prese,Common features of meningitis: signs of systemic infection : fever

11、(90-95%), anorexia,shock, alteration of mental status and consciousness neurological signs: increased intracranial pressure: headache, vomiting(82%), herniation meningeal irritation: nuchal rigidity(77%), kernig sign, brudzinski sign,Clinical manifestations,化脓性脑膜炎英文版,11,Common features of meningitis

12、,brudzinski sign,化脓性脑膜炎英文版,12,brudzinski sign化脓性脑膜炎英文版12,Seizure (20-30%) Focal or generalized Due to cerebritis, infarction, electrolyte disturbances Frequently noted with H influenzae & S pneumococcal meningitis Persist after 4th day and difficult to treat with poor prognosis,Clinical manifestatio

13、ns,化脓性脑膜炎英文版,13,Seizure (20-30%) Clinical m,Clinical manifestations,Alteration of mental status and consciousness Including: irritability, lethargy, stupor obtundation, coma Due to increased intracranial pressure, cerebritis, hypotension Often with pneumococcal or meningococcal meningitis Comatose p

14、atients with a poor prognosis,化脓性脑膜炎英文版,14,Clinical manifestations A,The symptoms and signs are not evident in neonates and infants younger than 3mo of age; and patients already received irregular antibiotic therapy.,Clinical manifestations,化脓性脑膜炎英文版,15,The symptoms and signs are no,Comparison of th

15、e manifestations of meningitis between different age groups,Clinical manifestations,化脓性脑膜炎英文版,16,Signs of systemic infectionInc,4. Diagnosis Earlier diagnosis and prompt initiation of effective antibiotic treatment is critical for minimizing sequelae of purulent meningitis. Suspected cases: febrile

16、infants with seizure, meningeal irritability, increased intracranial pressure, altered mental status Pay attention to the atypical symptoms and signs in neonate, infant and patient already received irregular antibiotic therapy,化脓性脑膜炎英文版,17,4. Diagnosis化脓性脑膜炎英文版17,Diagnosis is confirmed by analysis o

17、f cerebrospinal fluid ( CSF) Suggestion bacterial meningitis Increased pressure (90%) Appearance: slightly cloudy to purulent Raised white blood cells,consisting chiefly of polymorphonuclear leukocytes Raised protein concentration, decreased glucose concentration (80%),Diagnosis,化脓性脑膜炎英文版,18,Diagnos

18、is is confirmed by ana,Confirmation of the diagnosis: isolation from the CSF of a specific bacterial pathogen by microscopy or a positive culture or rapid antigen- detection test of CSF Gram-stained smear of CSF: identify the causative organism in 70-90% of cases CSF culture: positive in about 80% o

19、f cases. definitive diagnosis, determination of antibiotic sensitivity. PCR: amplifies bacterial DNA (H influenzae, N. meningitidis),Diagnosis,化脓性脑膜炎英文版,19,Confirmation of the diagnosi,5. Differential diagnosis Purulent meningitis caused by different pathogens Neissria meningitidis: Occur in epidemi

20、cs (type A,C), which is more common in spring, or sporadic all the year (type B,C,Y) Sudden onset with various cutaneous signs ( petechiae, purpura, or an erythematous macular rash),化脓性脑膜炎英文版,20,5. Differential diagnosis化脓性脑膜, Streptococcus pneumoniae: Young infants ( 1yr) are most susceptible popul

21、ation Peak season: spring and winter Easier to have subdural effusion and hydrocephalus Easily have a protracted course and relapse,Differential diagnosis,化脓性脑膜炎英文版,21, Streptococcus pneumoniae:Di,Haemophilus influenzae Occurs predominantly in infants 2mo to 2yr of age Many cases are in winter Highe

22、r incidence of subdural effusion Others pathogens: staphylococcus aureus, gramnegative enteric bacilli Special susceptible population: neonate, 3mo infants, malnutrition, immunodeficiency Severe infection, difficult to treat,Differential diagnosis,化脓性脑膜炎英文版,22,Haemophilus influenzae Differ,Meningiti

23、s caused by other microorganisms Viral meningitis/encephalitis: Less severe systemic infectious symptoms Usually not develop after 2-3weeks CSF: normal glucose,Differential diagnosis,化脓性脑膜炎英文版,23,Meningitis caused by other mi, Tuberculous meningitis Subacute onset and progress A history of close con

24、tact with known cases of tuberculosis Evidence of acute or healed tubercular infection on chest x-ray Tuberculin skin test : OT, PPD CSF,Differential diagnosis,化脓性脑膜炎英文版,24, Tuberculous meningitisDiffe,Cerebrospinal fluid in neurologic infection,化脓性脑膜炎英文版,25,DiseasePressureaspectTotal WBC,6. Complic

25、ations and sequelae6.1 Subdural effusion Definitive diagnosis: volume of fluid in subdural space 2ml, protein0.4g/L, Incidence: develop in 10-30% of patients, asymptomatic in 85-90% of patients; especially common in infants 4-6 month of age ( rare in children over 1yr);,化脓性脑膜炎英文版,26,6. Complications

26、 and sequelae化,Causative organisms: 45% of cases of meningitis caused by H influenzae, 30% by S pneumoniae, 9% by N meningitidis,subdural effusion,化脓性脑膜炎英文版,27,Causative organisms: 45% of,化脓性脑膜炎英文版培训课件,Diagnosis methods: Cranial translucent test B ultrasonic examination and CT Subdural space punctur

27、e,subdural effusion,normal,subdural effusion,化脓性脑膜炎英文版,29,Diagnosis methods:subdural ef,6.2 Ventriculitis,6.3 hydrocephalus,Complications,化脓性脑膜炎英文版,30,6.2 Ventriculitis6.3 hydrocep,Circulation of cerebrospinal fluid(CSF),化脓性脑膜炎英文版,31,Circulation of cerebrospinal f,6.2 Ventriculitis Usually occurs in

28、 neonates and infants (1yr), with severe prognosis The main cause is delayed diagnosis and treatment of meningitis.,Complications,化脓性脑膜炎英文版,32,6.2 VentriculitisComplication,Diagnosis: B ultrasonic examination or neuroimaging studies( CT, MRI): enlarged lateral ventricle Lateral ventricle puncture: b

29、acteria and inflammatory cells in ventricular fluid, WBC50 x106/L, Glucose400mg/L.,Ventriculitis,化脓性脑膜炎英文版,33,Diagnosis:Ventriculitis化脓性脑膜炎,Circulation of cerebrospinal fluid(CSF),化脓性脑膜炎英文版,34,Circulation of cerebrospinal f,6.3 hydrocephalus : Communicating hydrocephalus: adhered or destroyed arachn

30、oid granulation around the cistern at the base of the brain Obstructive hydrocephalus: following obstructed of the cerebral aqueduct, or the foramina of Magendie and Luschka6.4 others: Deafness, blindness, paralysis, epilepsy, mental retardation,Complications,化脓性脑膜炎英文版,35,6.3 hydrocephalus :Complica

31、tio,Treatment7.1 Antibacterial therapyTherapy principles: early treatment, antibiotics susceptible to pathogens and with high permeability through BBB, given intraveninously, enough dose, enough course of antibiotic therapy,化脓性脑膜炎英文版,36,Treatment化脓性脑膜炎英文版36, Susceptible to pathogens First choice: Ce

32、fotaxime, Ceftriaxone (3dr generation of cephalosporins, high permeability through BBB, products of metabolism also has effect, CSF sterilization within 24h) Other choice: Penicillin, Chloromycin, Cefuroxime, Ceftazidime ( delayed effect to make CSF sterile, high incidence of relapse and deafness),A

33、ntibacterial therapy,化脓性脑膜炎英文版,37, Susceptible to pathogensAnti,Antibiotic therapy of bacterial meningitis,化脓性脑膜炎英文版,38,EtiologyStandard antibiotics o,Maintenance fluid and thermal energy supplement: Fluid administration: 60-80ml/kg/day Fluid infusion with dehydration therapy,7.2 Supportive care,Tre

34、atment,化脓性脑膜炎英文版,39,Maintenance fluid and thermal, increased intracranial pressure Osmotic therapy: intravenous mannitol 0.5- 1g/kg/every time, q4-6h Combination with intravenous dexamethasone: 0.3-0.5mg/kg/day Endotracheal intubation and hyperventilation,Treatment,化脓性脑膜炎英文版,40, increased intracrani

35、al press,Subdural effusion Few volume could be absorbed with treatment spontaneously Subdural puncture: take out 15ml/each time (unilateral puncture), less than 30ml/each time ( bilateral puncture), everyday or every other day Stripping operation: for the cases not cure after 3-4weeks,Treatment,化脓性脑膜炎英文版,41,Subdural effusion Treatment化脓,Others: Ventriculitis : lateral ventricle puncture and injection of antibiotics locally Epilepsy: AEDs,Treatment,化脓性脑膜炎英文版,42,Others:Treatment化脓性脑膜炎英文版42,