3D类器官研究手册.docx

类器官概述2009年HanSQeVerS团队成功在体外培养出具有肠总总绒毛结构的胸关器官,目此美器官技术呈现出快速发国的势头.敬至2023年，科学家们已成功构建包括1®类、肠类、心血.肝S1.胃S1.肺、乳腺、视网投在内的各种正第或独曲类零官.类器官技术是近年来生物医学领域JB日突破性的的沿技术之一，己断泛应用于功能蜩透导.疾病模型病痛.药物发现和普选、个性化伴Sfi诊断.细胞治疗.再生医学等领域,成为如出生物医学彳解化研究的受要工具.类器官模型与其他模型比较一MSk1.fvBmreactor公晶rEApp1.ications4A三扁£、：3jDrugscreeningGeneIherapyBiobankingHumanorgandeve1.opment利用人多能干细曲(iPSCs)梅Ji类器官d缤义翔神州科技股t白阳公司Organoiddeve1.opmentIdentification/CH特点3D类西官2D#8胞系B三tS4s三c半生理琪里局限性耀生理烝型成功率高«低时何适中坦畦蟒适中低高遗传均定性高低高异质性高低高临床相关性高低«基因姆想SS困遵高通量箫迭三I3tS1.可实现希以实现生钺源建立可实现可实现堆以实现"自:1:10.10S6NEJMra1.806175;DOI;10,17s42242-021-0015Q-7类器官培养生长因子义髓神州开发了一系列废组生长因子,具有高活性、低内JS素'高批间TS性和高纯度等特点，以实现类器官的最佳生长.并确保荻为出立住好隹脸结果.这些产品出t多个客户的类器官平台验证,产品旗量已荻得市场的充分认可！覆盖多种类器官Q琪O肠道类需百胃类器有心脏类器日：O产品特点CT高纯度、高活性和高批间T1.性Q1.低内毒索水平A生物;能经细胞增电实眼.细胞毒性诩崎证A无标签或4版签表达V研究级和GM%R细抱因子可供选择gRSgSDS-PAGE/SEGHP1.C蝴0多种属：人、小鼠食蟹疑情可猴.大鼠和犬等J完者的质量控制体系胰腺类器官前列腺类黑白孕类SS白明星产品推荐细胞因子货号种属表达宿主i¾311标签内毒素ActivinA10429HNAHHuman,Mouse.Rat.Cynomo1.gus,RhesusHEK293Cdte295%&BioactiveNative<10EUJmgbasicFGF/FGF210014-HNAEHumanEb95%BioactiveNative<10E.,mgBMP41009HNAE2HumanE.0N95%BioactiveNative<1.0EU,gEGF10G05-HNAEHumanE.cofi95QBioactiveNative<5EuyEgFGF-101057J-HNAEHumanE.c095%BioactiveNative<5EU/mgGF1.10598HNAEHumanEc090ftBioactiveNativeKGF.FGF-710210H07EHumanE.coSi295%。BioactiveN-H<0.1EUtgNOggirVNoG10267-HNAHHumanHEK293CdiS299%。BioactiveNative<10EU,mgR-SpondmMRSP0111083-HNASHumanCHOStab1.eCe1.1.sBioactiveNative<10EU,mgWnt3aWNT007-02HHEK293CdfcS9tR,fiBioactiveC-hFc<10EU,mgfiHP1.aVbHieC正常组织类器官脑类器官细胞因子标志物抗体蛋白依号种属t三内毒素EGFIOeOSHNAE。HumanNative<5EUZmgEGFGMP-10605-HNAEOHumanNative<5EU，mgFGF210014-HNAEHumanNative<10EUmgFGF2GMP-U)O1.4-HNAE6HumanNative<10EU,mgFGFI912226-HNAEQHumanNative<10EUmgNOG10267-HNAHOHumanNative<10EMmgTGFB11O8O4-HNACHuman.Rhesus.Cynomo1.gus.CanineNative<1EUgINS11038HNAYHumanNativeShh10372H0H1HumanC-His<1EUjgBDNF50240M08HMouseC-His<1EUpgGDNF10561HNAE6HumanNative<10EUmgFGF816277HNAEHumanNativeDKK110170HHHumanC-HtS<1EU1.凶BMP41009HNAE2HumanNative<1EUpgCNTF11841H07EHumanN-HisFGF416043-HNAEftHumanNative<10EuymgCXC1.1213511HNCEHumanNative<1EU,gJejS货号种属抗体类型TUBB3101288-T34HumanRabbitPAbWB.ICG1FSOX2100106-R017HumanRabbitMAbIHC-PK67100130MM19HUmanMouseMAbIHC-PPAX2101696-T46HumanRabbitPAbWB.HCP.ICC,IF.IPEMX1205715T40HumanRabbitPAbWB.IHCPNeuropi1.in-210695-MM01HumanMouseMAbEUSA.E1.ISA(Det)Transthyre1.m20163OT1.OHumanRabbitPAbIHC-P.CCFMAP2100568-T08HumanRabbitPAbIHC-PNCadherin11039R020HumanRabbitMAbWB.EUSA.FC-M.ICG,IFCA1.B2203658T08HumanRabbHPAbIHCPDCX13498-MM01THumanMouseMAbICQIF肺类器官细胞因子标志物抗体蛋臼货号栉展内奇索EGF1O605HNAEOHumanNative<5EU.'mgEGFGMP-10605-HNAEHumanNative<5EU.,mgNOG10267HNAH电HumanNative<10EUmgRSPO1.11083-HNAS,HumanNative<10EUmgFGF210014-HNAEHumanNative<10EU,mgFGF2GMP-10014-HNAEQHumanNative<10EU1mgFGF71G210-H07EQHumanN-HisVIOEmngFGRGMP-10210-HNAE1.OHumanNative<10EU,mgK5F1010573HNAE&HumanNative<5EU,mgActrvinA10429HNAH。Human.Mouse.Rat.Cynomo1.gus.RhesusNative<10EU1mgActivinAGMP10429HNAHOHuman.Mouse,Rat,Cynomo1.gus.RhesusNative<10EU,mgBMP410609-HNAE2HumanNative<EUvgIe点货号并属类型TJPI102305-T02HumanRabbitPAbICC/IFUterog1.obin50291R122MouseRabbitMAbIHCPE-cadherin10204-R032HumanRabbitMAbIHCP.ICCIFFoxJ1.101152T36HumanRabbitPAbWB,IPp63100266R143HumanRabbitMAbIHCPS0X211O6-RO17HumanRabbitMAbIHC-PCytokeratin8108772-MM05HumanMouseMAbIHCP.ICG,IFCytokeratin17201453T1.oHumanRabbitPAbIHC-P.ICGIFQHP1.C-VerifiedOGMPGrade类器官培养实例（丹望医历是供）人肺热关器它坦织因手搐豆FGF21814HSE).FGF7(©：0HOT日,FGFIO<10573M«£|,RSPOI<1tO©HF4AS|.FGF4|：岚.MOG50688MO2H).EGF(50482M01W5O4B2MNCH)人肺关38官毁施因子推护FGF21.ii4HMA,FGF7102104076.FGFIOIO573HU½RSPOI1103hKASFGF4NOG"优H1.EGF(5O4B2M01H50482MKCH)甲状腺类器官缶白货号种属f三内需无EGF10605-HNAE，HumanNative<5EU'mgBSFGMP-10605-HNAEOHumanNative<5EUfmgN10267-HNAHHumanNative<10EU,mgRSP0111083HNAS6HumanNative<10EU,mgFGFIO10573-HNAE,HumanNative<5EUrmgFGF416043-HNAEOHumanNative<10EUngBMP410609HNAE2HumanNative<1EUUg嘲货号栉属拗帙里PAX8101554T10HumanRabbitPAbHCP.ICGIFThyroidperoxidase13®MM1.7HumanMouseMAbE1.ISA(Cap).IHC-PS1.C5A52O2914T08HumanRabbrtPAbIHCPFOXOI200239-T32HumanRabbrtPADWBTJPI102305-T02HumanRabbnPAbICOIF胃类器官蛋白俄号怜属ts内击器EGF10605HNAEHumanNative<5EU,mgEGFGMP-10605HNAECOHumanNative<5EUfmgNOG10267-HNAHHumanNative<10EU'mgRSPOI11083-HNASOHumanNative<10EU',mgFGF1O10573-HNAE。HumanNative<5EU1.mgFGF416043-HNAEHumanNative<10EU11gActivinA1O429HNAHfiHuman,Mouse.Rat,Cynomo1.gus.RhesusNative<10EU,mgActivinAGMP-10429-HNAHOHuman.Mouse.Rat.Cynomo1.gus,RhesusNative<10E1.1.'mgBMP410609HNAE2HumanNative<1EUUgWt3aWNT007-02HChFc<10EU,mgKsta货号种属抗体蟒应用FXF1101131T08HumanRabbitPAbIHCPK1.F5101389TO2HumanRabbPAbICGdFGATA4104604-T36HumanRabbnPAbWB.IPPDXI204167-T46HumanRabbi1.PAbWB.IHCP,CG,1F.IPS0X21001.OM»17HumanRabbitMAbIHCPEcadherin10204R032HumanRabbitMAbIHCP.ICC.1FACTA2100125-T40HumanRabb"PAbWB.IHCPCDX2101172-T32HumanRabbnPAbWBPGC12072-MM07HumanMouseMAbE1.ISA.IHC-PfiHP1.C-Verified0GMPGrade肾脏类器官距白货号种属1.三内蹲章BMP-210426-HNAE1Human.Mouse.Rat,Rhesus.CanineNative<10EU,mgBMP410609HNAE2HumanNative<1EUVgFGF210014-HNAEHumanNative<10EU,mgFGF2GMP10014HNAEOHumanNative<10EIKmgFGF416043-HNAE0HumanNative<10EU,mgFGF710210-H07E0HumanN-His<10EUrmgFGF7GMP-10210HNAE-1.OCHumanNative<10EU/mgFGF910262-HNAEHumanNative<10EUmgHGF10463HNAS0HumanNative<10EU'mgm货号粹履抗体类茎迹PAX2101696-T46HumanRabbnPAbWBjHC-PJCOIFtIPRDOX1.10058-T08HumanRabbrtPAbIHC-PNCadherin11039R020HumanRabbitMAbWB.E1.ISA.FCM.CC/IFAquaporin1202650-T08HumanRabbi!PAbIHC-PE-Cadherin10204-R032HumanRabbitMAbHCP,CG1FTIM-I70001-R202CanineRabbitMAbE1.ismhopVimentin100254R1HumanRabbitMAbWBJHCPCD311014MM13HumanMouseMAbFCMJCCdFPAX8101554T1.oHumanRabbitPAbIHC-P.ICG'1F内耳类器官Sa货号*标密内击索EGF106O5-HNAE，HumanNative<5EU/mgEGFGMPTO605-HNAEOHumanNative<5EU/mgIGF1.10598HNAY1HumanNativePOGFBB10572HNAEHumanNative<50EU,mgNGF11050-HNACHumanNative<1EUfyQBMP4106O9-HNAE2HumanNative<1EUVgFGF210014.HMAEHumanNative<10EU*mgFGF2GMP10014HNAEQHumanNative<10EU,mgm货号酢属抗体类型SiSPAX8101554-T10HumanRabbrtPAbHCP.ICG'IFE-cadherin10204-R032HumanRabbitMAbIHCP,ICCdFPAX2101696T46HumanRabbitPAbWB.IHC-P.ICQFfIPS0X21001.gR017HumanRabbitMAbIHC-PGATA3100714-T36HumanRabbitPAbWB.IPJagged1102IgeT1.oMouseRabbi1.PAbIHCP,ICOIFTUBB3101288.T34HumanRabbitPAbWB.ICGIFKRT18102193T44HumanRabbitPAbWB.IHCP1IPPCP4207078-T10HumanRabbitPAbIHCP,ICCdFANXA4203531-T44HumanRabbi!PAbWB.IH&P,IPSPARC1.1.10046MM06HumanMouseMAbEUSAFCM1CC1FQHP1.C-Verif1.edOGMPGrade知S言研铮次方主肿瘤类器官肝癌类器官柳货号种属抗蚀螂应用EpCAM10694-R028HumanRabb1.MAbWB.E1.ISA.EUSA(Det).IHC-P.FCM1CC1F,IPA1.phaJetoprotein12177MM27HumanMouseMAbcFGPC3100393T02HumanRabbitPAbcFbea-Catenn11279-R021HumanRag1.MAbEUSA.IHC-P.FCM.ICG4FK»671001.30-MMt9AHumanMouseMAbIHC-PKRT19100306-MM08HumanMouseMAbIHC-P，胃癌类器官3货号种属抗体螂应用CEACAMI10822R103HumanRabb<tMAbFCM1iccifKR710(X310MM02HumanMouseMAbIHC-PKRT20202163T42HumanRabbitPAbWB.IHC-P,ICeIFK岭71001.SaMM19HumanMouseMAbIHC-PE-cadherin10204-R032HumanRaMMAbIHC-P.ICG1FP5390001R002Cynomo1.gusRabbdMAbIHC-P.ICQ1.F膀胱癌类器官货号抗体蜉应用KR11100310MM02HumanMouseMAbIHC-PKRT20202163T42HumanRabbitPAbWB.IHC-P.ICQ1.FKi67100130-MK419HumanMouseMAbIHC-PKRT5100312-R176HumanRabtxtMAbWB.ICG1.FCytokeratin8108772MM05HumanMouseMAbIHC-P.ICQ1FP5390001-R002小Cynomo1.gusRabtxtMAbHCP.CQ1FKRTU100129-R101HumanRabbitMAbWB.IHC-P.IPF0XA1200169T46HumanRabbitPAbWB.IHC-P,CCFJPp6310026-R1.43HumanRabbitMAbIHC-PCD4412211-T62HumanRabbitPAbWB.EUSA.IHC-P.ICC1F.IP胆管癌类器官m货号种属抗爆类型KRT7100310-MM02HumanMouseMAbIHC-PMuC1.12123-MM05HumanMouseMAbEUSA,IHC-PP5390001R002Cynomo1.gusRabb<tMAbHC-P,ICCaFKRT19100306-MM08HumanMouseMAbIHC-PEpCAM10694-R028HumanRabbdMAbWB.E1.ISA.EUSA(Det).IHC-P.FCM.ICG1F,IPS100P12635-R116HumanRabmtMAbIHC-P.ICG1FN-Cadherin11039R020HumanRabtxtMAbVV8,EUSA.FCM.ICGIFNCAM10673-R131HumanRabtxtMAbEUSA.ICGIF当病理诊断吸抗体鼻咽癌类器官JEfS便号种履抗体类型Ki671OO13OMM19HumanMouseMAbIHC-PCD133108990TO8MouseRabbitPAbIHC-PCD4412211-T62HumanRabbitPAbWB.EUSAHC-P.CC1F.IP肺癌类器官m货号种属抗体她应用AHR101180-T10HumanRabbitPAbIHCP.ICa1.FNapsinA102221-T0HumanRabbitPAbIHC-PKRT71003WMM02HumanMouseMAbIHC-Pp63100266R143上HumanRabt>tMAbIHGPNCAM1O673-R131HumanRabbnMAbEUSA.ICGIFSynaptophysin1O0298R249HumanRabbdMAbIHC-P乳腺癌类器官m货号种属抗体类型ERa>ha100386T10HumanRabbitPAbIHC-P,ICQ1.FPR100362T08HumanRabbitPAbIHC-PHe<210004-R002AHumanRabt>tMAbEUSA,IHC-P.FCM.ICQFK»67100130-MM19HumanMouseMAbIHC-PKRTM100129-R101HumanRabb<tMAbWB.IHC-P.IPp6310026-R143÷HumanRabtotMAbIHC-PKRT510012R1.76HumanRabb<tMAbWB.CQ1FCy1.okeratin8108772MM05HumanMouseMAbIHC-P,ICG1.FPcadherin107913T08MouseRabbitPAbIHC-PE-cadherin10204-R032HumanRabb<tMAbIHC-P.ICG1FKRT18102193-T44HumanRabbitPAbWB.IHC-P1IP结直肠癌类器官搦货号种属抗体蜉应用MSH6100973R035小HumanRabbitMAbIHCP.CG1FKi67100130-MM19HumanMouseMAbIHC-PCDX2101172T32HumanRabbitPAbWBKRT20202163-T42HumanRabbitPAbWB.IHC-P.ICC-IFbeta-Caien11279RO21HumanRabtxtMAbEUSA,IHC-P.FCM.ICQFP-CK100675-T36HumanRabbitPAbWB.IPOCFM411639W12HumanMouseMAbEUSAFCM病雷獭则体前列腺癌类器官m货号种愿抗体类型姬K»67100130-MM19HumanMouseMAbIHC-PPTEN18729TO8HumanRabbitPAbIHC-PAR100272-MM05HumanMouseMAbICC/IFNkx3.11573T08HumanRabbitPAbIHC-Pp63100266R1433HumanRabb<tMAbIHC-PPSA10771MM03HumanMouseMAbIHC-PGSTFI100926T38HumanRabbitPAbWB.ICedFJPACTA2100125T40HumanRabbitPAbWB.IHCPKRT5100312-R176HumanRabtxtMAbWB.ICG1FCyiokeratin8108772MM05HumanMouseMAbHCP.ICQ1.FE-Cadherin10204-R032HumanRabbitMAbIHC-P.CG1FVimentin100254-R001÷HumanRabbitMAbWB.IHC-PKRTUI(X)I四R1.O1.HumanRabtxtMAbWB.IHCP.IP卵巢癌类器官货号种B!抗体螂p5390001-R002Cynomo1.gusRabt>tMAbIHC-P.ICG1FPAX8101554-T10HumanRabbitPAbIHC-P.ICG1.FCytokerat1.n81O8772MMO5HumanMouseMAbIHC-P.ICG1.FERa1.phaKXB86-T1OHumanRabbitPAbIHC-P.CG1FHE4126O9RP02HumanRabbitPAbEUSA.IHC-PPR100362-T08HumanRabbitPAbIHC-PKRT71003WMM02HumanMouseMAbIHC-PEcadherin10204R032HumanRabb<tMAbIHC-P.ICG1.FHer21(X>04-R002AHumanRabbdMAbEUSA.IHOP.FCM.ICGIFKRT202O2163-T42HumanRabbitPAbWB.IHC-P.ICG1.FK»67100130-MM19HumanMouseMAbIHC-PCD911029MM01HumanMouseMAbFCMjCG1.FKRT19100306-MM08HumanMouseMAbIHC-PEpCAM10694R028HumanRabt>tMAbWB.EuSAE1.ISA(Dot).IHOP.FCM,ICC'1F,IPA1.DH1A111388-MM03HumanMouseMAbWB.EUSA.FCM.ICC1FCD4412211-MMO2HumanMouseMAbFCM1.CC"F胰腺癌类器官m货号种属抗体她应用Synaptophysin100298R249HumanRabbitMAbIHC-PKi671001.30MM19t21.HumanMouseMAbIHC-PChromograninA100256MMo2HumanMouseMAbIHC-PKRT19100306MM08HumanMouseMAbIHaPMUC112123MM05HumanMouseMAbEUSA1IHC-P当痫理诊断级抗体:!以义盟神州科技段份有正公SJ.热门产品推荐热销生长因子产品妞抱因子货号种属表达宿主类s#宫类生BMP210426-HNAEHuman,Mouse,Rat.Rhesus.CanineE.oV肝脏.腿CNTF80012RNAERatE.cov腿CXC1.1210118-H01HHumanHEK293Ce1.1.s50025MNAEMouseE.cV13511-HNCEHumanE.coii脑1011SHNAEHumanEcoti13511-H07EHumanE.coHDKK157248-M08HMouseHEK293Cei1.s眼三EEGF10605-H01HHumanHEK293Ce1.1.s50482-MNAYMouseYeast8Sf1.,B.IB.RE.CT.W邮I®.50432M01HMousoHEK293Ce1.1.s乳腰.内耳.血总、甲级除50482MNCHMouseHEK293Ce1.1.sFGF250037M07EMousoECOfi顺道.心腔.脑.肝及肺、胃脏.端1.帚列糠.孔IS1.内耳、管FGF750394M07EMouseE.Hff三.肺.1361.91.®16124-HMAEFGF816277.HNAEHumanHumanE.coH脑E.VFGF910262-H01HHumanHEK293Cei1.s肾脏GDNF10561-HNCHHumanHEK293Ce1.1.sHGF5Q038-MNAHMouseHEK293Cei1.s1三80429-RNAHRatHEK293Cei1.sGF110598HNAEHumanE.8V50437-MNAYMouseS道、乳dB、内耳Yeast1.2213059HNAEHumanE.期肠道INS11038-HNAYHumanYeast脑.肝脏UF50756-MNAHMouseHEK293Ce1.1.s心脏14890-H08HHumanHEK293Ce1.1.sNGF50385-MNACMouseCHOStab1.eCe1.1.s内耳NOG50688-M02HMouseHEK293Ce1.1.s10267.H02HHumanHEK293Ce1.1.s三S.H.IB.肝脏.肺.懒一画两.乳腺.甲状腺10267-H08HHumanHEK293Ce1.1.s扫抱因子货号种H表达宿主烈他类里1065-H01HHumanHEK293Ce1.1.sNRG1.11609HNCHHumanHEK293Ce1.1.s10658-H08HHumanHEK293Ce1.1.s1ie09-HO1H2HumanHEK293Ce1.1.sOSM10452-H08H50112Mo8HHumanMouseHEK293Ce1.1.sHEK293Ce1.1.sKK10572HOTYHumanYeastPDGF13081-H07YHumanYeastWS10273-H01HHumanHEK293Ce1.1.s11083HO8HHumanHEK293Ce1.1.sRSPOI50316M08S1103-H0H1