怡神保内科.ppt

周围神经病治疗剂,糖尿病并发症周围神经病,病变部位,临床表现,感觉减退+腱反射减弱+,肌肉萎缩麻痹、瘫痪(III,IV),直立性低血压,食道无张力胃轻瘫肠道功能紊乱,无张力性膀胱阳茎勃起障碍,后果,残疾褥疮被忽视截肢,肌无力斜视,眩晕,呕吐低血糖腹泻、便秘,排尿障碍阳萎,Source:WHO 80686,modified by Assal&Froesch(1978),皮肤,肌肉,消化道,小动脉,泌尿生殖系统,人民健康 我们欢欣,MECOBALAMIN TABLETS,（甲钴胺片）,周围神经病治疗剂,双盲研究证明怡神保治疗周围神经病变的效果,190 例,(20 个研究单位),安慰剂,DBCC 1500g/day,怡神保 1500g/day,总改善率,对症状的改善,53.3,57.8,77.3,46.7,42.2,22.7,0.05,0.025,46.7,22.7,42.2,53.3,57.8,77.3,P0.025,P0.05,行走和起立异常的改善率,感觉异常的改善率,安慰剂,DBCC,怡神保,安慰剂,DBCC,30.8,27.3,30.4,41.7,83.3,52.3,怡神保,MECOBALAMIN TABLETS,（甲钴胺片）,人民健康 我们欢欣,周围神经病治疗剂,改善糖尿病神经病变患者的主观症状,0,0.5,1.0,1.5,2.0,2.3,42例,麻木,疼痛,虚弱,痛性痉挛,阳萎,NSNS P0.005 NSP0.02 NS P0.002 NS P0.03 NS,NS:无异常,Devathasan G.et al.:Clinical Trials Journal.23(2),p.130,1986,平均评分,安慰剂,MECOBALAMIN TABLETS,（甲钴胺片）,人民健康 我们欢欣,