热性感染相关性癫痫综合征诊治课件.ppt

,热性感染相关性李光乾,概述儿科常见的癫痼性脑病有大田原综合征、Dravet综合征、Landau-Kleffner综合征、Lennox-Gastaut综合征等癫瘸脑病的共同特点是发作频繁、多样、药物难以控制;伴有严重认知功能障碍;病因多样,可为特发性或症状性;预后不良,概述近年来,临床报道有这样一类少见的病例既往健康的儿童,在突发持续发热后,出现难治性部分性癫痼或癫痼持续状态(SE),急性期常有意识障碍,后存在认知障碍及药物难治性癫痼部分患儿脑脊液(CSF)淋巴细胞轻度增高及MRI提示脑内有异常信号如颞区、岛叶和基底节区高信号等;但病原学检查仅部分患儿血清或鼻咽部发现感染的病原,CSF从未找到病原尸检或脑活检均未发现炎症细胞浸润,概述诊断:脑炎?,概述1323-1328.2019BRIEF COMMUNICATIONFebrile infection-related epilepsy syndrome(FirEs):A nonencephalitic encephalopathy in childhood#Andreas van Baalen,mArtin Hausler,*Rainer Boor,tAxel Rohr,SUrgen Sperner4IGcrhard Kurlemann,#Axel Panzer,*Ulrich Stephani,and#Gerhard Klugertment of Neuropediatrics,University Medical Center Schleswig-Hoktein,Christian-Albrechts.UniversitatAdolescent Medicine,University Lubeck,Lubeck,Germany:Department of Neuroped iatric,UKM,Munster,Germany:#DRKWestend clinie Berlin,Berlin,Germany and Neuropediatric Department,BHZ Yogtareuth,vogtareuth,Germany,