新生儿坏死性小肠结肠炎课件.pptx

Neonatal necrotizing enterocolitis,Kunyao Yu,Outline,Risk factorBacterial&NECIntestinal defense mechanismClinical presentation Bells stageTreatment,Risk Factor,PrematureLow birth weight(1500g)Broad-spectrum antibioticsFeeding,Bacterial&NEC,Intestinal bacterial colonization in the infant-Delivery method-Feeding,Intestinal defense mechanism,PeristalsisGastric acidProteolytic enzymesIntestinal mucusCell surface glycoconjugatesCells tight junctionsImmunology,Clinical presentation,Abdominal sign:distension,vomiting,hematocheziaFeeding intoleranceLethargyTemperature instabilityHypotension,Image,Bells stage,Treatment,Stage Ia:-NPOStage Ib-IIb/IIIa:-NPO-Broad spectrum antiboticsStage IIIa-IIIb:-Surgery/Peritoneal drain,Probiotics-treat?,Probiotics-treat?,What is the optimal probiotic organism(s)?What is the optimal administration including assessment of what patients are the best candidates for treatment?What is the optimal probiotic dose?What is the best timing of administration?What is the most efcacious length of treatment?,THANK YOU,